Abstract
A series of N-(beta-D-glucopyranosyl)amides 5d-i were synthesized by PMe(3) mediated Staudinger reaction of O-peracetylated beta-D-glucopyranosyl azide (1) followed by acylation with carboxylic acids 3d-i and subsequent Zemplén deacetylation. The new compounds were tested for their inhibitory activity against rabbit muscle glycogen phosphorylase and the structure-activity relationships of these compounds are also discussed in this paper.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amides / chemical synthesis
-
Amides / chemistry*
-
Amides / pharmacology*
-
Animals
-
Dioxanes / chemical synthesis
-
Dioxanes / chemistry*
-
Dioxanes / pharmacology*
-
Glycogen Phosphorylase, Muscle Form / antagonists & inhibitors*
-
Glycogen Phosphorylase, Muscle Form / metabolism*
-
Molecular Structure
-
Rabbits
-
Structure-Activity Relationship
Substances
-
Amides
-
Dioxanes
-
Glycogen Phosphorylase, Muscle Form